Important: A multidisciplinary team consisting of a physician, critical care nurse, and respiratory therapist should be available to monitor ventilated patients at all times. Additionally, a clinical lab capable of timely reporting of blood gases and other common ICU laboratory markers should be available to enable the clinical team to make appropriate decisions and adjustments.
Acute Respiratory Distress Syndrome
Those patients with ARDS would preferentially receive mechanical ventilation by standard ICU ventilators. A manual resuscitator is meant as a backup should institutions run out of traditional ventilators, and for patients with milder forms of lung disease that require less sophisticated modes and features.
Changes in lung mechanics (compliance) can be a result of acute and chronic lung conditions. In general, lung compliance is affected by a multitude of factors; in ARDS, fluid is present in the alveoli and/or interstitial space (between the alveoli and a capillary blood vessel) and results in changes in the diffusion of gases between the alveoli and blood vessel. Other conditions include:
The safe limit for ventilation therapy has not yet been determined. In the life-and-death situation we are currently facing, this will give patients a chance until an ICU or OR ventilator becomes available. We are actively engaging with animal testing laboratories to determine what, if any, these limitations may be. Further, we plan to perform multi-day trials in pigs to evaluate the safety of longer-term MIT E-Vent use.